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Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.
As a result, the Fullscript Integrative Medical Advisory team advises using an evidence-informed approach to protocol development. To simplify this process for practitioners, we have assembled a sampling of evidence-based standardized protocols that practitioners can use as a foundation when developing individualized protocols.
To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.
The following protocols were developed using only A through C-quality evidence. These are categorized as follows:
A Systematic review or meta-analysis
B Randomized Double Blind Placebo Controlled (RDBPC) 2+ studies and/or 1 study with 50 + subjects
C Randomized Double Blind Placebo Controlled (RDBPC) 1 study
Please refer to the complete Rating Scale for further information.
The ingredients included in these protocols are based on a review of existing clinical research, with a priority placed on systematic reviews and meta-analyses, classified as A in the Rating Scale.
These protocols are intended to form a foundation for developing individualized treatment plans. Clinician discretion is highly advised, as ingredients can vary in safety and effectiveness, depending on the needs of the individual patient.
Ingredient-Based Protocol: Insomnia
2.5 to 3mg, total per day, minimum three weeks1,2
- Increase in sleep quality was observed without adverse effects1,2
- During the withdrawal period of melatonin, carryover of the effect on sleep latency time was observed on the following night1
- Improvement in sleep onset latency, sleep-wake patterns, and delayed sleep phase syndrome3
- The lowest dosing of exogenous melatonin is recommended in order to mimic the natural physiological circadian rhythm of melatonin4
Search for Melatonin in the Fullscript catalog.
320mg, total per day of magnesium citrate, minimum 7 weeks5
- Improvement of PSQI score, which includes improvements in sleep quality, sleep onset latency, sleep duration, sleep disturbance, daytime dysfunction, and hypnotic drug scores5
- In addition to improving PSQI score, magnesium reduced early morning awakenings6
Search for Magnesium in the Fullscript catalog.
Valeriana officinalis (Valerian)
1060mg, total per day, minimum 4 weeks7
- Improvement in sleep quality and overall effectiveness observed in clinical insomnia7,9
- Reduction in sleep latency was observed in a concentrated extract of a 5.3:1 ratio8
Search for Valeriana officinalis in the Fullscript catalog.
Adding Protocols to your Fullscript Catalog
Create a Template
- Click the “Prescriptions” button
- Click “Manage your prescription templates”
- Click “Create a new template”
- Add a title, products, dosing, message, and attachments
- Click “Save Template”
Templates can be accessed and applied when creating a new prescription for your patients.
Write a Prescription
- Click the “New Prescription” button
- Click the “Templates” button in the right-hand menu column
- Click the “Apply” button beside the template you wish to apply
- Modify as needed
- Click the “Send to Patient” button!
Create a Category
- Click the Catalog button
- Click the “Your Favorites” tab
- Click “Add Category” and add name
- Add products
Categories can be used for quick reference or for patient use when accessing the catalog (depending on catalog settings).
Visit the Fullscript Integrative Clinical Education Hub for a full review of the literature used to develop this protocol.
We’d be happy to help you create a protocol containing these ingredients in your Fullscript catalog! Contact our Customer Success team for assistance.
1 (C) - https://academic.oup.com/sleep/article/35/10/1395/2596070
2 (B) - https://www.ncbi.nlm.nih.gov/pubmed/24718775
3 (A) - https://www.ncbi.nlm.nih.gov/pubmed/28648359
4 (A) - https://www.ncbi.nlm.nih.gov/pubmed/24802882
5 (B) - https://www.ncbi.nlm.nih.gov/pubmed/21199787
6 (C) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
7 (B) - https://www.ncbi.nlm.nih.gov/pubmed/21775910
8 (C) - https://www.ncbi.nlm.nih.gov/pubmed/17486686
9 (A) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394901/