In this article:
Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.
As a result, the Fullscript Integrative Medical Advisory team advises using an evidence-informed approach to protocol development. To simplify this process for practitioners, we have assembled a sampling of evidence-based standardized protocols that practitioners can use as a foundation when developing individualized protocols.
To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.
The following protocols were developed using only A through C-quality evidence. These are categorized as follows:
A Systematic review or meta-analysis
B Randomized Double Blind Placebo Controlled (RDBPC) 2+ studies and/or 1 study with 50 + subjects
C Randomized Double Blind Placebo Controlled (RDBPC) 1 study
Please refer to the complete Rating Scale for further information.
The ingredients included in these protocols are based on a review of existing clinical research, with a priority placed on systematic reviews and meta-analyses, classified as A in the Rating Scale.
These protocols are intended to form a foundation for developing individualized treatment plans. Clinician discretion is highly advised, as ingredients can vary in safety and effectiveness, depending on the needs of the individual patient.
Ingredient-Based Protocol: Menopause-Hot Flashes
400-800IU, total per day, minimum 4 weeks1,2
- Severity score and frequency of hot flashes was significantly improved compared to placebo1,2
Search for Vitamin E in the Fullscript catalog.
50-120mg, total per day, minimum 12 weeks3,4
- Hot flash frequency and intensity was shown to be decreased compared to placebo4,5
- Supplementation for at least 48 weeks is required in order to obtain 80% of maximum effect6
Search for Isoflavones in the Fullscript catalog.
Evening Primrose oil
1000mg, total per day, minimum 6 weeks7
- Frequency and severity of hot flashes compared to placebo was significantly improved7
- HFRDIS (Hot Flash Related Daily Interference Scale) was ameliorated especially regarding social activities, relations with others, and sexuality score7
Search for Evening Primrose oil in the Fullscript catalog.
Red Clover (Trifolium pratense)
80mg dried leaves, once per day, minimum 12 weeks8,9
- Frequency and severity of hot flashes compared to placebo was significantly improved8,9
- Other subjective symptoms like vaginal dryness and atrophy showed improvement10
Search for Red Clover in the Fullscript catalog.
Adding Protocols to your Fullscript Catalog
Create a Category
- Click the Catalog button
- Click the “Your Favorites” tab
- Click “Add Category” and add name
- Add products
Categories can be used for quick reference or for patient use when accessing the catalog (depending on catalog settings).
Create a Template
- Click the “Prescriptions” button
- Click “Manage your prescription templates”
- Click “Create a new template”
- Add a title, products, dosing, message, and attachments
- Click “Save Template”
Templates can be accessed and applied when creating a new prescription for your patients.
Write a Prescription
- Click the “New Prescription” button
- Click the “Templates” button in the right-hand menu column
- Click the “Apply” button beside the template you wish to apply
- Modify as needed
- Click the “Send to Patient” button!
Visit the Fullscript Integrative Clinical Education Hub for a full review of the literature used to develop this protocol.
We’d be happy to help you create a protocol containing these ingredients in your Fullscript catalog! Contact our Customer Success team for assistance.
1 (B) - https://www.ncbi.nlm.nih.gov/pubmed/17664882
2 (B) - https://www.ncbi.nlm.nih.gov/pubmed/9469333
3 (A) - https://www.ncbi.nlm.nih.gov/pubmed/30475519
4 (B) - https://www.ncbi.nlm.nih.gov/pubmed/20025635
5 (A) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389700/
6 (A) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386944/
7 (B) - https://www.ncbi.nlm.nih.gov/pubmed/23625331
8 (A) - https://www.ncbi.nlm.nih.gov/pubmed/28160855
9 (B) - https://www.ncbi.nlm.nih.gov/pubmed/25581426
10 (A) - https://www.ncbi.nlm.nih.gov/pubmed/26471215