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Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.
As a result, the Fullscript Integrative Medical Advisory team advises using an evidence-informed approach to protocol development. To simplify this process for practitioners, we have assembled a sampling of evidence-based standardized protocols that practitioners can use as a foundation when developing individualized protocols.
To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.
The following protocols were developed using only A through C-quality evidence. These are categorized as follows:
A Systematic review or meta-analysis
B Randomized Double Blind Placebo Controlled (RDBPC) 2+ studies and/or 1 study with 50 + subjects
C Randomized Double Blind Placebo Controlled (RDBPC) 1 study
Please refer to the complete Rating Scale for further information.
The ingredients included in these protocols are based on a review of existing clinical research, with a priority placed on systematic reviews and meta-analyses, classified as A in the Rating Scale.
These protocols are intended to form a foundation for developing individualized treatment plans. Clinician discretion is highly advised, as ingredients can vary in safety and effectiveness, depending on the needs of the individual patient.
Ingredient-Based Protocol: Polycystic Ovarian Syndrome (PCOS)
500 mg, three times per day, minimum 3 months
- Reductions in total testosterone, free androgen index, fasting glucose, fasting insulin and HOMA-IR, and increases in SHBG.1
- Decreases in BMI, lipid parameters and total FSH requirement, and an increase in live birth rate with fewer gastrointestinal adverse events.1
- Decrease the waist circumference and waist-to-hip ratio, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol as well as increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin.2
Search for Berberine in the Fullscript catalog.
1 g, twice per day, minimum 6 months
- Improved the regularity of the menstrual cycle, the Acne Score, the endocrine and metabolic parameters and the insulin-resistance 3
- Effective in improving ovarian function and metabolism in patients with PCOS, and reduced hyperandrogenism better 4
Search for D-Chiro-Inositol in the Fullscript catalog.
1 g, twice per day, minimum 6 months
- Significantly decreased serum total testosterone, modified Ferriman-Gallwey (mF-G) scores and serum high-sensitivity C-reactive protein (hs-CRP) levels5
- Meta-analysis demonstrates that myo-inositol improves HOMA index and increases the E2 (estradiol) level6
Search for Myo-Inositol in the Fullscript catalog.
200 ug, per day, minimum 8 weeks
- Demonstrated significant reductions in fasting plasma glucose, insulin levels, homeostatic model of assessment for insulin resistance, and a significant increase in quantitative insulin sensitivity check index 7
- Significantly decreased serum triglycerides, VLDL and total cholesterol concentrations
- Contributes to increases in plasma total antioxidant capacity and a significant reduction in malondialdehyde values 7
- Overall reduction in BMI and free testosterone concentration 8
Search for Chromium Picolinate in the Fullscript catalog.
Adding Protocols to your Fullscript Catalog
Create a Template
- Click the “Prescriptions” button
- Click “Manage your prescription templates”
- Click “Create a new template”
- Add a title, products, dosing, message, and attachments
- Click “Save Template”
Templates can be accessed and applied when creating a new prescription for your patients.
Write a Prescription
- Click the “New Prescription” button
- Click the “Templates” button in the right-hand menu column
- Click the “Apply” button beside the template you wish to apply
- Modify as needed
- Click the “Send to Patient” button!
Create a Category
- Click the Catalog button
- Click the “Your Favorites” tab
- Click “Add Category” and add name
- Add products
Categories can be used for quick reference or for patient use when accessing the catalog (depending on catalog settings).
Visit the Fullscript Integrative Clinical Education Hub for a full review of the literature used to develop this protocol.
We’d be happy to help you create a protocol containing these ingredients in your Fullscript catalog! Contact our Customer Success team for assistance.
1 (B) - https://www.ncbi.nlm.nih.gov/pubmed/23869585
2 (B) - https://eje.bioscientifica.com/view/journals/eje/166/1/99.xml
3 (B) - https://www.ncbi.nlm.nih.gov/pubmed/25670222
4 (B) - https://www.ncbi.nlm.nih.gov/pubmed/24351072
5 (B) - https://www.ncbi.nlm.nih.gov/pubmed/28485095
6 (A) - https://www.ncbi.nlm.nih.gov/pubmed/29052180
7 (A) - https://www.ncbi.nlm.nih.gov/pubmed/29307112
8 (A) - https://www.ncbi.nlm.nih.gov/pubmed/28595797